Prevention and modern treatment are the weapons of cardiologists in the fight against cardiovascular disease

Every year on 29 September we celebrate World Heart Day. The motto in 2024 is “Act with Heart”, a call expressed in a petition that focuses political and public attention on improving access to prevention, diagnosis and treatment of cardiovascular disease. They claim over 20.5 million lives a year and are the undisputed number 1 killer, leading the black statistics ahead of all forms of cancer and chronic respiratory diseases combined. On this occasion, we talk to Assoc. Prof. Dobri Hazarbasanov – one of the leading cardiologists in the country, head of the cardiology department at the high-tech hospital complex ‘Heart and Brain’ in Burgas.

According to the World Heart Federation, 80% of premature deaths due to cardiovascular disease can be prevented. What are the steps?

Over the past 50 years, thanks to large randomized and epidemiological studies, it has been established which treatments improve the survival of patients with cardiovascular disease (CVD). Their effective implementation in North American and Western European countries has led to a significant reduction in CVD mortality. Lifestyle changes are key: increased physical activity, smoking cessation and limiting intake of carbohydrates and saturated animal fats. A huge role is also played by the effective organisation of emergency medical care, intensive cardiac care units, patients’ access to modern diagnostic and therapeutic methods: echocardiography, cardiac catheterisation, coronary angiography and percutaneous coronary intervention (PCI), coronary by-pass surgery, implantation of pacemakers and defibrillators. This is an established standard of medical management that, together with effective medical therapy, has led to a fourfold reduction in CVD mortality in the United States over 40 years. Of course, this is possible when therapy is truly administered according to medical standards and recommendations and all patients have access to it. This includes: beta-blockers, PCIs, thrombolytics, statins, ACE inhibitors, widespread use of aspirin for secondary prevention in acute myocardial infarctions, effective control of arterial hypertension, SGLT-2 blockers, MRA antagonists, mechanical thrombectomy in acute ischemic stroke.

The Bulgarian Heart Institute has been working for 15 years to improve access to specialised treatment for CVD.

Yes, this is our long-term goal – 15 years ago a structure of centres was established, available 7 days a week, 24 hours a day, for the treatment of Acute Myocardial Infarction/MI/, centres for endo-vascular therapy of peripheral arterial disease. Since 2 years, high-tech hospital complexes ‘Heart and Brain’ in Pleven and Burgas for treatment of acute stroke with thrombolysis and mechanical thrombectomy are functioning. Patients have permanent access to specialists: cardiologist, cardiac surgeon, vascular surgeon, neurologist and neurosurgeon and outreach examinations in small settlements.

As every year, the Bulgarian Cardiology Institute will celebrate September 29 with a number of activities in the cities of Burgas, Pleven, Yambol, Varna, Veliko Tarnovo, Shumen.

How do modern diagnostic methods change the approach to treatment?

The application of the latest as well as established modern methods in the diagnosis of CVD is a condition without which effective treatment cannot be carried out. This is based on the work of our multidisciplinary teams with the latest generation of imaging and diagnostic equipment for interventional cardiology, vascular surgery, and endovascular interventions, neurointerventions (mechanical thrombectomy), electrophysiology, performing coronary and valvular cardiac surgery with classical and endoscopic access and hybrid approach for revascularization, transcatheter valve interventions (TAVI) – all in one place.

The leading cardiac surgeon from ‘Heart and Brain’ Burgas, Assoc. Prof Kornovski, is an expert in valve and coronary surgery at the European Heart Association and STS and his team works in collaboration with Thierry Carrel from Switzerland. I myself have worked as a proctor for TAVI implantations in the UK, Morocco, RSM, Lebanon, Cyprus, Romania, Ukraine, Iran and Bulgaria, and over the years have gained experience in interventional correction of paraprosthetic regurgitation in collaboration with Eric Eeckhout from Switzerland.

What are the most common complaints of your patients, what do they seek you for most often?

The most frequent reason why patients seek us are the manifestations of heart failure: shortness of breath, fatigue, arrhythmias. All cardiovascular diseases eventually lead to heart failure, which is the most significant pandemic in the last 20 years.

Symptoms of acute myocardial infarction are prolonged chest pain – we work daily and long-term to better inform patients, including on the Bulgarian Cardiology Institute website, and make patients aware of the symptoms, approaches, diagnoses and treatments of certain cardiovascular diseases. Over the years we have organised and successfully implemented numerous campaigns to raise awareness, prevention and control of CVD.

Symptoms of acute stroke are sudden onset of paralysis of limbs or impairment in speech, vision and/or consciousness, and we also prepare information materials on these symptoms.

In recent years, cardiologists have been sounding the alarm that cardiovascular disease is getting younger. What has been your experience?

This trend is observed all over the world. Reduced physical activity and the consumption of large amounts of high-calorie food is leading to an epidemic of overweight and obesity, which in turn is leading to the premature development of type 2 diabetes, arterial hypertension, dyslipidaemias associated with obesity – this is also a pronounced trend in children, which is particularly worrying.

Non-surgical removal of a large bile duct stone performed by a multidisciplinary team at ‘Heart and Brain’

Gastroenterologists at ‘Heart and Brain’ Burgas performed for the first time laser destruction of a large-sized gallstone in a patient with a gallstone detected during a previous examination. This is the second attempt to remove the mass, after the doctors judged that the manipulation could not be performed in the traditional way by removal with a balloon or metal basket. With the help of a cholangioscope, a thin endoscope through which it is possible to view the bile ducts, the stone is visualized and subsequently fragmented using a laser fiber (Thulium laser) and equipment provided by the urology department. The patient recovered within only two days and was discharged without complications after the procedure. Thus, surgical intervention was avoided, which is usually severely tolerated and leads to prolonged hospital stay.

Non-operative removal of bile duct stones

Gallstone disease is common. When gallbladder concrements are found, patients undergo surgical treatment. However, when pathological formations get into the bile ducts, they cause yellowing of the skin and eyes and in these cases are the subject of gastroenterology. A highly specialized procedure called endoscopic retrograde cholangiopancreatography is performed to remove the stones from the bile ducts. In a not insignificant percentage of cases, specialists encounter large concrements (more than 15 mm) that cannot be removed by this method alone.The gastroenterology department in the high-tech hospital complex ‘Heart and Brain’ in Burgas has additional equipment, the so-called cholangioscopy, with which the bile ducts are examined.

Assoc. Prof. Natalia Chilingirova, Head of the Oncology Center in ‘Heart and Brain’ Pleven: In the fight against cancer, the patient is what unites all teams

– Assoc. Prof. Chilingirova, what is the thing that motivates you, given the weight of your profession and specialty?

– Patient focus is our main driver in the fight against cancer. Our goal is a personal approach to everyone and the opportunity for the patient to comment in detail on all aspects of their disease with us, the specialists at the , Heart and Brain’ Oncology Centre. Hearing the diagnosis of cancer is like entering another world – full of new terminology and overwhelming decisions. That’s why we doctors are united around a very special mission: to stop the progression of cancer and give our patients a good quality of life. In addition to removing barriers in doctor-patient communication, the goal is to encourage the patient to trust the doctor, to ask questions in order to be informed and to make decisions. Trust is built when we, as professionals, have the courage to say all that matters in an individualized therapeutic approach and take responsibility for our actions. We insist on transparency and know that open and honest communication is critical to therapeutic success.

– How do you achieve complexity in cancer patient care?

– In medicine, and especially in oncology, treatment complexity is key. At the , Heart and Brain Cancer Center, we approach everything we do as one organism. We apply advanced and proven technologies – working in sync and in collaboration with all clinics and departments to provide the best health care and patient empathy. In the radiotherapy department, as indicated, patients can be treated with the unique Gamma Knife, and minimally invasive surgical interventions with the da Vinci robot are part of routine practice. As cancer is now also defined as a disease of the genome, precise diagnosis – based on a range of specific genetic tests – is the cornerstone of successful treatment. That’s why we invest in a highly specialized, certified to the highest modern standards and one-of-a-kind genetics laboratory. At our clinical research centre, patients get much-needed fast access to the latest innovative drug treatments as well as the latest clinical trials in oncology.

The Oncology Centre in , Heart and Brain Pleven is the first in Bulgaria to be a member of OECI (Organisation of European Cancer Institutes), therefore the comprehensive care and access to innovations at every stage of diagnosis, treatment and follow-up has established us as a centre for highly specialised and advanced care.

– What is the place of innovation?

– Innovativeness is about the challenge – constantly learning and getting better. We create and boldly apply new thinking that is valued by patients and colleagues across the country and Europe. We embrace discovery and innovation, knowing that exploring the unknown is the best way to drive progress in cancer treatment and care. We attract, develop and retain specialists who have the curiosity, passion and drive to continuously learn and challenge themselves in the search for a better approach to better outcomes for our patients. Our oncologists participate in a number of international forums as well as international research and clinical projects. They collaborate with colleagues from around the world and put into practice groundbreaking discoveries, even in our understanding of cancer as a disease. And this improves the possibilities for prevention, diagnosis and treatment.

Although the Cancer Centre is one of the youngest in the country, in just the last two years it has managed to establish itself as one of the leading centres and has already gained international recognition.